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KMID : 1098420110190010054
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Korean Journal of Medicinal Crop Science
2011 Volume.19 No. 1 p.54 ~ p.65
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Enhancement of Cosmeceutical Activities of Berberis koreana Bark by High Pressure and Ultrasonification Extraction Processes
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Jin Ling
Ha Ji-Hye
Choi Woon-Yong
Seo Yong-Chang
Kim Ji-Seon
Kim Young-Ock
Cha Sun-Woo
Kim Jin-Cheol
Lee Hyeon-Yong
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Abstract
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This study was performed to investigate the enhancement of cosmeceutical activities of Berberis koreana bark by different extraction processes. The extracts are WE (water extract at 100℃, control), USE (ultrasonification for 1 hours at 60℃ with water), HPE (high pressure for 5 minutes at 60℃ with water) and USE + HPE (ultrasonification process for 1 hours after high pressure for 5 minutes at 60℃ with water), respectively. The cytotoxicity of the extracts was in the range of 24.02~26.94% at 1.0 ㎎/㎖ concentration. The USE + HPE showed the lowest cytotoxicity. Compared to the WE, total phenolic and flavonoid contents in the USE + HPE increased to 121.5% and 154.2%. The USE + HPE showed the highest activity at 1.0 ㎎/㎖ concentration in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging, inhibition activity of xanthine oxidase and superoxide dismutase (SOD)-like test, respectively. Tyrosinase inhibition of WE, USE, HPE and USE + HPE at 1.0 ㎎/㎖ concentration was measured as 17.72, 19.62, 22.83 and 24.16%, respectively. Hyaluronidase inhibition activities of the USE + HPE were higher than 20.8%~29.5% of the WE. Our results suggested that the extracts from ultrasonification process after high pressure extraction has relatively high cosmeceutical activities, and that the bark of Berberis koreana could be considered as a candidate of new functional cosmetic agents.
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KEYWORD
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Berberis koreana Bark, Ultrasonification, High Pressure, Cosmeceutical Activities
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